Antiviral Platform
Viral infections are highly contagious and therefore widely spread. There are generally two types of viruses: enveloped and non-enveloped. Enveloped viruses cause some of the most severe diseases known in humans, such as Covid-19, influenza, Herpes (HSV-1, HSV-2), Hepatitis B and C, Hemorrhagic Fever (Ebola Virus Disease), and HIV-1 and HIV-2 (the causes of AIDS).
There are general publications indicating a pronounced anti-viral activity of Cinnamon. More specifically, it has been discovered that immediately inhibits viral activity by adhering to the viral envelope or spikes. Thus, it can potentially be applied against a variety of enveloped viruses, to serve as a broad antiviral platform.Cinnovir
Initial studies have been conducted and further studies are warranted. Once the effectiveness of Cinnovir is proven, our solutions will have a broad-spectrum application, including fighting Covid-19, herpes, influenza and several animal viruses.
Schematic Illustration
Legend:
Left image: the “flowers” symbolize viruses; the large brown arc is the PPF. The graphic depicts attachment of the PPF to the viral envelope/spikes.
Central image: comparison of the two scenarios – the left one, where the unabated viruses have penetrated the host cell of the body, vs. the right one, where PPF is attached to the viral envelope/spikes, thus the virus is “locked” and is unable to penetrate the cell.
Right image: the immune system is identifying and attacking the “locked” virus.
Reference List: Scientific and Pre-Clinical Data on Cinnamon Extract Antiviral Properties
- Premanathan et al. 2000. Indian J Med Res, Sep;112:73-7.
- Barak, I., Ovadia, M. 2005. “Natural inhibitor of influenzaA-PR8 extracted from cinnamon”. 18th ICAR meeting, April 11-14, 2005, Barcelona, Spain. Antiviral Research Vol 65, A65.
- Ovadia M. et al. 2006. “Anti Viral Preparation Obtained from a Natural Cinnamon Extract,” USP9364511.
- Sevillia, G., Kamensky, M., Finger, A., Ovadia, M. 2007. “Cinnamon Extract Inhibits Avian Influenza H9N2 Both in-vitro and in-vivo.” Options for the control of Influenza, p. 467-469.
- Gueta, K., Kamensky, M., Finger, A., Ovadia, M. 2008. “Immunization against Newcastle Disease Virus Using Cinnamon Fraction.” Annual meeting of Veterinary Institute, Bet-Dagan. Israel Journal of Veterinary Medicine 63(2).
- Fink, R.C., Roschek, B., Alberte, R.S. 2009. International Medical Press, 2040-2066.
- Ovadia, M., Kallily, Y., Bernstein, E. 2009. “Cinnamon fraction neutralizes avian influenza H5N1 both in-vitro and in-vivo.” 22nd ICAR meeting, 3-7 May 2009, Miami Beach, Florida. Antiviral Research 82(2), A35.
- Kallily, I. Kamensky, M. Finger, A. Ovadia, M. 2010. “Immunization against Newcastle disease virus using cinnamon fraction.” Modern Veterinary Vaccines and Adjuvants (MVVA) conference, November 17-19, Budapest, Hungary.
- Conell, B.J. et al. 2016. “A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation”. PLOS ONE |OI:10.1371/journal.pone.0165386 October 27, 2016.
- Munazza, F., Zaidi, N.S., Amraiz, D., Afzal F. 2016. “In Vitro Antiviral Activity of Cinnamomum cassia and its Nanoparticles Against H7N3 Influenza A Virus.” Microbiol. Biotechnol. 26(1), 151-159.
- Kurt, L. et al. 2021. “Cinnamon and Hop Extracts as Potential Immunomodulators for Severe COVID-19 Cases” OPINION ARTICLE Plant Sci., https://doi.org/10.3389/fpls.2021.589783